TAS1R1
Reseptor rasa tipe 1 anggota 1 inggih punika protein sané ring manusa kakode olih gen TAS1R1 . [1]
Protein sané kakode olih gen TAS1R1 inggih punika reseptor sané mapaiketan sareng protein G antuk pitung domain trans-membran miwah pinaka pahan saking reseptor rasa asam amino heterodimer T1R1+3. Reseptor puniki kawentuk pinaka dimer saking protein TAS1R1 lan TAS1R3 . Napi malih protein TAS1R1 nenten mawiguna ring jaba pawentukan heterodimer 1+3. [2] Reseptor TAS1R1+3 sampun mabukti prasida nyawis asam amino L- sakéwanten nénten ring D-enantiomer utawi senyawa tiosan. Kawagedan puniki ngiket asam amino L-, khususnyane L- glutamin, ngawinang angga prasida ngrasayang umami, utawi rasa gurih. [3] Makudang-kudang varian transkrip sané nyiriang makudang-kudang isoform sané matiosan sampun kapanggihin ring gen puniki, sané minab nlatarang wates rasa sané matiosan pantaraning individu antuk rasa umami . [4] [5] Kualitas sané becik tiosan saking protein TAS1R1 miwah TAS1R2 inggih punika aktivitas spontannyané nénten wénten domain ekstraseluler miwah ligan sané ngiket. [6] Puniki minab maartos domain ekstraseluler ngatur fungsi reseptor antuk nambakin tindakan spontan taler ngiket ligan sané ngaktifang sekadi L- glutamin.
- ↑ "Entrez Gene: TAS1R1 taste receptor, type 1, member 1".
- ↑ Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS (2001). "Mammalian sweet taste receptors". Cell. 106 (3): 381–390. doi:10.1016/S0092-8674(01)00451-2. PMID 11509186.
- ↑ Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS (2002). "An amino-acid taste receptor". Nature. 416 (6877): 199–202. Bibcode:2002Natur.416..199N. doi:10.1038/nature726. PMID 11894099.
- ↑ "Entrez Gene: TAS1R1 taste receptor, type 1, member 1".
- ↑ White BD, Corll CB, Porter JR (1989). "The metabolic clearance rate of corticosterone in lean and obese male Zucker rats". Metabolism: Clinical and Experimental. 38 (6): 530–536. doi:10.1016/0026-0495(89)90212-6. PMID 2725291.
- ↑ Sainz E, Cavenagh MM, LopezJimenez ND, Gutierrez JC, Battey JF, Northup JK, Sullivan SL (2007). "The G-protein coupling properties of the human sweet and amino acid taste receptors". Developmental Neurobiology. 67 (7): 948–959. doi:10.1002/dneu.20403. PMID 17506496.