Cebur nuju daging

Serotonin

Saking Wikipédia
Serotonin
Skeletal formula of serotonin
Data klinis
Sinonim5-HT, 5-Hydroxytryptamine, Enteramine, Thrombocytin, 3-(β-Aminoethyl)-5-hydroxyl solution , Thrombotonin
Data fisiologis
Jaringan sumberraphe nuclei, enterochromaffin cells
Jaringan targétsystem-wide
Reséptor5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7
AgonisIndirectly: SSRIs, MAOIs
Prékursor5-HTP
BiosintésisAromatic L-amino acid decarboxylase
MétabolismeuMAO
Identifiers
Nomor CAS
PubChem CID
IUPHAR/BPS
ChemSpider
KEGG
PDB ligan
ECHA InfoCard100.000.054 Uah ring Wikidata

Serotonin ( /ˌsɛrəˈtoʊnɪn, ˌsɪərə-/ ) [1] [2] [3], taler kauningin pinaka 5-hidroksitriptamin ( 5-HT ), inggih punika neurotransmiter monoamin sane madue makudang-kudang fungsi ring sistem saraf pusat (SSP) lan taler jaringan tepi. Punika nyarengin ring suasana hati, kognisi, pahala, pembelajaran, ingatan, lan proses fisiologis sakadi muntah lan vasokonstriksi. [4] Ring SSP, serotonin ngatur suasana hati, napsu makan, lan sirep. [5] [ sumber medis sane nenten andel ] [6]

Akéhan serotonin ring angga—kirang langkung 90%—kasintesis ring saluran pencernaan olih sel enterochromaffin, ring dija ipun ngatur gerakan usus. [7] [8] [9] Punika taler kakaryanin antuk jumlah sane alitan ring inti raphe batang otak, sel Merkel kulit, sel neuroendokrin paru-paru, lan sel reseptor rasa lidah. Sesampun kasekresi, serotonin kaambil olih trombosit ring getih, sane ngelepasin rikala pembekuan mangda prasida ngalimbakang vasokonstriksi lan agregasi trombosit. [10] Sawetara 8% saking serotonin ring angga kasimpen ring trombosit, miwah 1-2% kapanggihin ring SSP. [11]

Serotonin mawiguna pinaka vasokonstriktor miwah vasodilator manut ring konsentrasi miwah konteks, ngawinang hemostasis miwah pengaturan tekanan darah. [12] Puniki maguna pisan ring ngrangsang neuron myenteric miwah nincapang motilitas pencernaan saking siklus pengambilan miwah pelepasan ring trombosit miwah jaringan sané nampek. [13] Sekadi biokimia, serotonin inggih punika indoleamin sane kasintesis saking triptofan lan kametabolisme utamanyane ring hati dados asam 5-hidroksiindoasetat (5-HIAA).

Serotonin kaaptiang olih makudang-kudang kelas antidepresan, minakadi inhibitor pengambilan kembali serotonin selektif (SSRI) miwah penghambat pengambilan kembali serotonin-norepinefrin (SNRI), sané ngalanglangin pengambilan kembali ring sinapsis mangda prasida nincapang kadarnyané. Puniki kapanggihin ring akéhan buron bilateral, rumasuk serangga, laba-laba miwah cacing, [14] miwah taler kapanggihin ring jamur miwah entik-entikan . [15] Ring entik-entikan miwah racun serangga, punika madué fungsi pertahanan antuk ngawinang rasa sakit. [16] Serotonin sane kalepas olih amoeba patogen prasida ngawinang diare ring usus manusa, [17] nanging kawentenannyane ring biji lan buah-buahan kaanggep prasida ngawinang pencernaan lan ngawentenang penyebaran biji. [18] [ verifikasi nénten prasida ]

Lis pustaka

[uah | uah wit]
  1. ↑ Jones D (2003). Roach P, Hartmann J, Setter J (eds.). English Pronouncing Dictionary. Cambridge: Cambridge University Press. ISBN 978-3-12-539683-8. Unknown parameter |orig-date= ignored (help)
  2. ↑ Mal:Dictionary.com
  3. ↑ Mal:MerriamWebsterDictionary
  4. ↑ Young SN (November 2007). "How to increase serotonin in the human brain without drugs". Journal of Psychiatry & Neuroscience. 32 (6): 394–399. PMC 2077351. PMID 18043762.
  5. ↑ Sangare A, Dubourget R, Geoffroy H, Gallopin T, Rancillac A (October 2016). "Serotonin differentially modulates excitatory and inhibitory synaptic inputs to putative sleep-promoting neurons of the ventrolateral preoptic nucleus" (PDF). Neuropharmacology. 109: 29–40. doi:10.1016/j.neuropharm.2016.05.015. PMID 27238836.
  6. ↑ Rancillac A (November 2016). "Serotonin and sleep-promoting neurons". Oncotarget. 7 (48): 78222–78223. doi:10.18632/oncotarget.13419. PMC 5346632. PMID 27861160.
  7. ↑ "Microbes Help Produce Serotonin in Gut". California Institute of Technology. 2015-04-09. Kaaksés 2022-06-03.
  8. ↑ "Serotonin". The Medical Biochemistry Page. Indiana University School of Medicine. Kaaksés 1 December 2009.
  9. ↑ Berger M, Gray JA, Roth BL (2009). "The expanded biology of serotonin". Annual Review of Medicine. 60: 355–366. doi:10.1146/annurev.med.60.042307.110802. PMC 5864293. PMID 19630576.
  10. ↑ Schlienger RG, Meier CR (2003). "Effect of selective serotonin reuptake inhibitors on platelet activation: can they prevent acute myocardial infarction?". American Journal of Cardiovascular Drugs. 3 (3): 149–162. doi:10.2165/00129784-200303030-00001. PMID 14727927.
  11. ↑ (Thesis). Missing or empty |title= (help)
  12. ↑ Vanhoutte PM (February 1987). "Serotonin and the vascular wall". International Journal of Cardiology. 14 (2): 189–203. doi:10.1016/0167-5273(87)90008-8. PMID 3818135.
  13. ↑ Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY (April 2015). "Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis". Cell. 161 (2): 264–276. doi:10.1016/j.cell.2015.02.047. PMC 4393509. PMID 25860609.
  14. ↑ Huser A, Rohwedder A, Apostolopoulou AA, Widmann A, Pfitzenmaier JE, Maiolo EM, Selcho M, Pauls D, von Essen A, Gupta T, Sprecher SG, Birman S, Riemensperger T, Stocker RF, Thum AS (2012). "The serotonergic central nervous system of the Drosophila larva: anatomy and behavioral function". PLOS ONE. 7 (10): e47518. Bibcode:2012PLoSO...747518H. doi:10.1371/journal.pone.0047518. PMC 3474743. PMID 23082175.
  15. ↑ Ramakrishna A, Giridhar P, Ravishankar GA (June 2011). "Phytoserotonin: a review". Plant Signaling & Behavior. 6 (6): 800–809. Bibcode:2011PlSiB...6..800A. doi:10.4161/psb.6.6.15242. PMC 3218476. PMID 21617371.
  16. ↑ Erspamer V (1966). "Occurrence of indolealkylamines in nature". 5-Hydroxytryptamine and Related Indolealkylamines. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 132–181. doi:10.1007/978-3-642-85467-5_4. ISBN 978-3-642-85469-9.
  17. ↑ McGowan K, Kane A, Asarkof N, Wicks J, Guerina V, Kellum J, Baron S, Gintzler AR, Donowitz M (August 1983). "Entamoeba histolytica causes intestinal secretion: role of serotonin". Science. 221 (4612): 762–764. Bibcode:1983Sci...221..762M. doi:10.1126/science.6308760. PMID 6308760.
  18. ↑ Feldman JM, Lee EM (October 1985). "Serotonin content of foods: effect on urinary excretion of 5-hydroxyindoleacetic acid". The American Journal of Clinical Nutrition. 42 (4): 639–643. doi:10.1093/ajcn/42.4.639. PMID 2413754.
Kapolihang saking "https://ban.wikipedia.org/w/index.php?title=Serotonin&oldid=235360"