Rurung dopaminergik

Rurung dopaminergik ( jalur dopamin, proyeksi dopaminergik ) ring otak manusa nyarengin ring proses fisiologis miwah parilaksana minakadi gerakan, kognisi, fungsi eksekutif, hadiah, motivasi, miwah kontrol neuroendokrin . ^[1] Soang-soang jalur inggih punika seperangkat neuron proyeksi, sané kawangun antuk neuron dopaminergik individu.

Petang jalur dopaminergik utama inggih punika jalur mesolimbik, jalur mesokortikal, jalur nigrostriatal, miwah jalur tuberoinfundibular . Jalur mesolimbik miwah jalur mesokortikal ngwentuk sistem mesokortikolimbik. Kalih jalur dopaminergik tiosan sané patut kapinehin inggih punika saluran hipotalamospinal miwah jalur insertohipotalamus.

Penyakit Parkinson, gangguan hiperaktif defisit perhatian (ADHD), gangguan penggunaan zat ( kecanduan), lan sindrom kaki gelisah (RLS) prasida kaiket sareng disfungsi ring jalur dopaminergik spesifik.

Neuron dopamin saking jalur dopaminergik ngamargiang sintesis miwah nglepas neurotransmiter dopamin . ^[2] ^[3] Enzim tirosin hidroksilase miwah dopa dekarboksilase kaperluang ring sintesis dopamin. ^[4] Enzim puniki makakalih kakaryanin ring awak sel neuron dopamin. Dopamin kasimpen ring sitoplasma miwah vesikel ring terminal akson. Pelepasan dopamin saking vesikel kakawitin olih depolarisasi membran sané kamedalang olih propagasi potensial aksi. ^[4] Akson neuron dopamin nglimbakang makasami jalur sané sampun katentuang.

Cingak taler

Kelompok sel dopaminergik

Lis pustaka

↑ Alcaro A, Huber R, Panksepp J (December 2007). "Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective". Brain Research Reviews. 56 (2): 283–321. doi:10.1016/j.brainresrev.2007.07.014. PMC 2238694. PMID 17905440.
↑ "Beyond the Reward Pathway". Learn Genetics. University of Utah. Kaarsipin saking versi asli tanggal 2010-02-09. Kaaksés 2009-10-23.
↑ Le Moal M (1995). "Mesocorticolimbic Dopaminergic Neurons: Functional and Regulatory Roles". Ring Bloom FE, Kupfer DJ (eds.). Psychopharmacology: the fourth generation of progress. New York: Raven Press. ISBN 978-0-7817-0166-2. Kaarsipin saking versi asli tanggal 5 February 2018.
↑ ^4,0 ^4,1 Harsing LG (2008). "Dopamine and the Dopaminergic Systems of the Brain". Ring Lajtha A, Vizi ES (eds.). Handbook of Neurochemistry and Molecular Neurobiology. Boston, MA: Springer US. pp. 149–170. doi:10.1007/978-0-387-30382-6_7. ISBN 978-0-387-30351-2.

[1] Alcaro A, Huber R, Panksepp J (December 2007). "Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective". Brain Research Reviews. 56 (2): 283–321. doi:10.1016/j.brainresrev.2007.07.014. PMC 2238694. PMID 17905440.

[urlBeyond_the_Reward_Pathway-2] "Beyond the Reward Pathway". Learn Genetics. University of Utah. Kaarsipin saking versi asli tanggal 2010-02-09. Kaaksés 2009-10-23.

[projection-3] Le Moal M (1995). "Mesocorticolimbic Dopaminergic Neurons: Functional and Regulatory Roles". Ring Bloom FE, Kupfer DJ (eds.). Psychopharmacology: the fourth generation of progress. New York: Raven Press. ISBN 978-0-7817-0166-2. Kaarsipin saking versi asli tanggal 5 February 2018.

[Harsing_2000-4] 4,0 ^4,1 Harsing LG (2008). "Dopamine and the Dopaminergic Systems of the Brain". Ring Lajtha A, Vizi ES (eds.). Handbook of Neurochemistry and Molecular Neurobiology. Boston, MA: Springer US. pp. 149–170. doi:10.1007/978-0-387-30382-6_7. ISBN 978-0-387-30351-2.

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