Reseptor dopamin sane D2
Reseptor dopamin D 2, taler kasengguh D 2 R, inggih punika protein sané, ring manusa, kakode olih gen DRD2 . Risampune makarya saking laboratorium Paul Greengard sampun nyihnayang indik reseptor dopamin inggih punika genah tindakan tamba antipsikotik, makudang-kudang kelompok, rumasuk Solomon H. Snyder lan Philip Seeman nganggen tamba antipsikotik sane madaging label radio anggen ngidentifikasi napi sane mangkin kauningin pinaka reseptor dopamin D 2 . [1] Reseptor dopamin D 2 inggih punika reseptor utama ring akehnyane tamba antipsikotik . Struktur DRD2 ring kompleks sareng risperidon antipsikotik atipikal sampun katentuang. [2] [3]
Reseptor D 2 mapaiketan sareng subtipe G i saking protein G. Reseptor sané mapaiketan sareng protein G puniki prasida nambakin aktivitas adenil siklas. [4]
Ring bikul, pangaturan ekspresi permukaan D 2 R olih sensor kalsium neuronal-1 (NCS-1) ring gyrus dentate nyarengin ring eksplorasi, plastisitas sinaptik miwah ngwentuk memori. [5] Penelitian sampun nyihnayang peran potensial D 2 R ring ngambil ingatan takut ring korteks prelimbik [6] lan ring pembelajaran diskriminasi ring inti accumbens. [7]
Ring lalat, aktivasi autoreseptor D 2 nyaga neuron dopamin saking sel sané padem sané kamedalang olih MPP +, racun sané nulad patologi penyakit Parkinson. [8]
Yadiastun dopamin sane becik ngawinang stabilisasi kognitif D 1 R, D 2 R sane dados mediator fleksibilitas kognitif ring manusa. [9] [10] [11]
- ↑ Madras BK (2013). "History of the discovery of the antipsychotic dopamine D2 receptor: a basis for the dopamine hypothesis of schizophrenia". Journal of the History of the Neurosciences. 22 (1): 62–78. doi:10.1080/0964704X.2012.678199. PMID 23323533.
- ↑ Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL (March 2018). "Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone". Nature. 555 (7695): 269–273. Bibcode:2018Natur.555..269W. doi:10.1038/nature25758. PMC 5843546. PMID 29466326.
- ↑ "NIMH » Molecular Secrets Revealed: Antipsychotic Docked in its Receptor". www.nimh.nih.gov (ring Inggris). 29 January 2018. Kaaksés 2018-11-26.
- ↑ Usiello A, Baik JH, Rougé-Pont F, Picetti R, Dierich A, LeMeur M, Piazza PV, Borrelli E (November 2000). "Distinct functions of the two isoforms of dopamine D2 receptors". Nature. 408 (6809): 199–203. Bibcode:2000Natur.408..199U. doi:10.1038/35041572. PMID 11089973.
- ↑ Saab BJ, Georgiou J, Nath A, Lee FJ, Wang M, Michalon A, Liu F, Mansuy IM, Roder JC (September 2009). "NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory". Neuron. 63 (5): 643–56. doi:10.1016/j.neuron.2009.08.014. PMID 19755107. Check date values in:
|date=(help) - ↑ Madsen HB, Guerin AA, Kim JH (November 2017). "Investigating the role of dopamine receptor- and parvalbumin-expressing cells in extinction of conditioned fear". Neurobiology of Learning and Memory. 145: 7–17. doi:10.1016/j.nlm.2017.08.009. PMID 28842281.
- ↑ Iino Y, Sawada T, Yamaguchi K, Tajiri M, Ishii S, Kasai H, Yagishita S (March 2020). "Dopamine D2 receptors in discrimination learning and spine enlargement". Nature. 579 (7800): 555–560. Bibcode:2020Natur.579..555I. doi:10.1038/s41586-020-2115-1. PMID 32214250.
- ↑ Wiemerslage L, Schultz BJ, Ganguly A, Lee D (August 2013). "Selective degeneration of dopaminergic neurons by MPP(+) and its rescue by D2 autoreceptors in Drosophila primary culture". Journal of Neurochemistry. 126 (4): 529–40. doi:10.1111/jnc.12228. PMC 3737274. PMID 23452092.
- ↑ Cameron IG, Wallace DL, Al-Zughoul A, Kayser AS, D'Esposito M (April 2018). "Effects of tolcapone and bromocriptine on cognitive stability and flexibility". primary. Psychopharmacology. 235 (4): 1295–1305. doi:10.1007/s00213-018-4845-4. PMC 5869902. PMID 29427081.
- ↑ Yee DM, Braver TS (February 2018). "Interactions of Motivation and Cognitive Control". Current Opinion in Behavioral Sciences. 19: 83–90. doi:10.1016/j.cobeha.2017.11.009. PMC 6051692. PMID 30035206.
- ↑ Persson J, Stenfors C (2018). "Superior cognitive goal maintenance in carriers of genetic markers linked to reduced striatal D2 receptor density (C957T and DRD2/ANKK1-TaqIA)". PLOS ONE. 13 (8): e0201837. Bibcode:2018PLoSO..1301837P. doi:10.1371/journal.pone.0201837. PMC 6101371. PMID 30125286.